PhD Thesis Defense: Victor Golyaev
The role of viral effector proteins in suppression of plant antiviral defenses based on RNA silencing and innate immunity
grosser Hörsaal Pharmazie-Historisches Museum, Totengässlein 3
During the course of his PhD work, Victor and his colleagues performed comparative investigation of viral effector proteins, RTBV P4 and CaMV P6, from two distanly-related pararetroviruses, Rice tungro bacilliform virus (RTBV) and Cauliflower mosaic virus (CaMV), respectively, in order to understand their role in the suppression of plant antiviral defenses based on RNA silencing and innate immunity. Particularly, we showed that RTBV protein P4, of previously unknown function, is able to suppress cell-to-cell spread of mobile silencing signals and oxidative burst in Nicotiana benthamiana, while CaMV P6 being the main determinant of virus host range mediates the suppression of plant innate immunity responses, such as ROS burst and SA-dependent autophagy.