Mechanisms of translational control evolved by plants viruses

Viruses have evolved various specialized mechanisms to express genes from compact viral genomes. We are interested in the mechanisms of translation initiation such as ribosome shunting and leaky scanning, in which the scanning ribosomes bypass large regions of viral mRNAs and initiate translation of several consecutive ORFs from a single polycistronic viral mRNA.

Selected publications:

Pooggin MM, Rajeswaran R, Schepetilnikov MV, Ryabova LA. 2012. Short ORF-Dependent Ribosome Shunting Operates in an RNA Picorna-Like Virus and a DNA Pararetrovirus that Cause Rice Tungro Disease. PLoS Pathogens 8: e1002568.

Pooggin MM, Futterer J, Hohn T. 2008. Cross-species functionality of pararetroviral elements driving ribosome shunting. PLoS One 3: e1650.

Pooggin MM, Ryabova LA, He X, Fütterer J and Hohn T. 2006. Mechanism of ribosomal shunting in rice tungro bacillifom virus. RNA 12: 841-850.

Pooggin MM, Fütterer J, Skryabin KG and Hohn T. 2001. Ribosome shunt is essential for infectivity of cauliflower mosaic virus. Proceedings of National Academy of Sciences of U S A 98: 886-891.